Photodynamic therapy with verteporfin to induce regression of aggressive retinal astrocytomas

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BDNF reduces the retinal toxicity of verteporfin photodynamic therapy.

PURPOSE Verteporfin photodynamic therapy (PDT) is the most effective treatment for age-related macular degeneration, using laser activation of a photosensitizing dye to achieve closure of choroidal neovascularization. Although PDT preferentially affects pathologic vessels, it can also cause collateral damage to the overlying retina. In the current study, it was found that the neuroprotective ag...

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Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapy.

PURPOSE A prior study showed that brain-derived neurotrophic factor (BDNF) rescues photoreceptors from collateral retinal damage caused by photodynamic therapy (PDT). This study was conducted to determine whether ciliary neurotrophic factor (CNTF), a combination of BDNF and CNTF, or pigment epithelial cell-derived growth factor (PEDF) might protect photoreceptors and retinal function more effec...

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Photodynamic therapy with verteporfin for macular degeneration

Use of a structured format No Abstract No Abstract No Abstract Explicit description of clinical question Description of databases and other information sources Description of selection criteria Description of methods for validity assessment Description of methods for data abstraction Description of study characteristics Description of quantitative data synthesis Description of characteristics o...

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Dramatic Regression of Presumed Acquired Retinal Astrocytoma with Photodynamic Therapy

Photodynamic therapy (PDT) has been used for treatment of various intraocular tumors including choroidal hemangioma, vasoproliferative tumor, amelanotic choroidal melanoma and choroidal neovascular membrane due to choroidal osteoma. This case report documents the effect of PDT for a presumed acquired retinal astrocytoma. A 42-year-old female with a juxtapapillary acquired astrocytoma was treate...

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ژورنال

عنوان ژورنال: Acta Ophthalmologica

سال: 2008

ISSN: 1755-375X

DOI: 10.1111/j.1755-3768.2007.01151.x